diff --git a/python-cramjam.spec b/python-cramjam.spec
index 1ac1650..f179f39 100644
--- a/python-cramjam.spec
+++ b/python-cramjam.spec
@@ -154,10 +154,24 @@ export RUSTFLAGS='%{build_rustflags}'
 # tests/test_variants.py:55: DecompressionError
 k="${k-}${k+ and }not test_variants_different_dtypes[blosc2]"
 %endif
+
 # Some tests in test_variants.py may produce segmentation faults
 # https://github.com/milesgranger/cramjam/issues/190
 k="${k-}${k+ and }not (test_variants and [blosc2)"
 
+%if 0%{?fedora} > 41
+# Test failures in test_variants_decompress_into with recent hypothesis
+# versions
+# https://github.com/milesgranger/cramjam/issues/201
+#
+# It is hard to be really sure what is going on here. The failures are
+# concerning, and might (or might not) reflect a serious problem. Nevertheless,
+# since the problem appears to be linked to newer hypothesis versions, there’s
+# not reason to believe that the package has *new* problems. It *might* have
+# newly *revealed* problems. This merits further investigation.
+k="${k-}${k+ and }not test_variants_decompress_into"
+%endif
+
 %pytest -k "${k-}" -v -n auto
 %endif