diff --git a/python-cryptography.spec b/python-cryptography.spec
index 3670a2a..e6fe8cd 100644
--- a/python-cryptography.spec
+++ b/python-cryptography.spec
@@ -98,6 +98,11 @@ cd ../..
 %build
 export RUSTFLAGS="%build_rustflags"
 export OPENSSL_NO_VENDOR=1
+# Temporary work-around for using pyo3 0.20 with Python 3.13 on ELN; This can
+# be dropped when a cryptography release bumps to pyo3 >= 0.22
+%if 0%{?rhel}
+export PYO3_USE_ABI3_FORWARD_COMPATIBILITY=1
+%endif
 %pyproject_wheel