diff --git a/.gitignore b/.gitignore
index ea7f662..4ad8197 100644
--- a/.gitignore
+++ b/.gitignore
@@ -69,3 +69,9 @@
 /cryptography-43.0.0-vendor.tar.bz2
 /cryptography-44.0.0.tar.gz
 /cryptography-44.0.0-vendor.tar.bz2
+/cryptography-45.0.2.tar.gz
+/cryptography-45.0.2-vendor.tar.bz2
+/cryptography-45.0.3.tar.gz
+/cryptography-45.0.3-vendor.tar.bz2
+/cryptography-45.0.4.tar.gz
+/cryptography-45.0.4-vendor.tar.bz2
diff --git a/12091.patch b/12091.patch
deleted file mode 100644
index 96ef95a..0000000
--- a/12091.patch
+++ /dev/null
@@ -1,34 +0,0 @@
-From 68369a6dbae71a9314ac0ecc8b88c435600cb4e9 Mon Sep 17 00:00:00 2001
-From: Johan Andersson <johan.andersson@lime.tech>
-Date: Tue, 3 Dec 2024 00:43:31 +0100
-Subject: [PATCH] build: remove cargo.toml files from wheels
-
----
- pyproject.toml | 8 +++++---
- 1 file changed, 5 insertions(+), 3 deletions(-)
-
-diff --git a/pyproject.toml b/pyproject.toml
-index 4266e3bd5ba4..0378e78815e3 100644
---- a/pyproject.toml
-+++ b/pyproject.toml
-@@ -101,15 +101,17 @@ include = [
-     "src/_cffi_src/**/*.c",
-     "src/_cffi_src/**/*.h",
- 
--    "**/Cargo.toml",
--    "**/Cargo.lock",
-+    "Cargo.toml",
-+    "Cargo.lock",
-+    "src/rust/**/Cargo.toml",
-+    "src/rust/**/Cargo.lock",
-     "src/rust/**/*.rs",
- 
-     "tests/**/*.py",
- ]
- exclude = [
-     "vectors/**/*",
--    "src/rust/target/**/*",
-+    "target/**/*",
-     "docs/_build/**/*",
-     ".github/**/*",
-     ".readthedocs.yml",
diff --git a/python-cryptography.spec b/python-cryptography.spec
index 110249d..16b4d7e 100644
--- a/python-cryptography.spec
+++ b/python-cryptography.spec
@@ -5,24 +5,26 @@
 %global srcname cryptography
 
 Name:           python-%{srcname}
-Version:        44.0.0
+Version:        45.0.4
 Release:        %autorelease
 Summary:        PyCA's cryptography library
 
 # cryptography is dual licensed under the Apache-2.0 and BSD-3-Clause,
 # as well as the Python Software Foundation license for the OS random
 # engine derived by CPython.
-License:        (Apache-2.0 OR BSD-3-Clause) AND PSF-2.0
+# Rust crate dependency licenses:
+# Apache-2.0
+# Apache-2.0 OR MIT
+# BSD-3-Clause
+# MIT
+# MIT OR Apache-2.0
+License:        (Apache-2.0 OR BSD-3-Clause) AND PSF-2.0 AND Apache-2.0 AND BSD-3-Clause AND MIT AND (MIT OR Apache-2.0)
 URL:            https://cryptography.io/en/latest/
 Source0:        https://github.com/pyca/cryptography/archive/%{version}/%{srcname}-%{version}.tar.gz
                 # created by ./vendor_rust.py helper script
 Source1:        cryptography-%{version}-vendor.tar.bz2
 Source2:        conftest-skipper.py
 
-# Merged for 45.0.0+
-# https://github.com/pyca/cryptography/pull/12091
-Patch: 12091.patch
-
 ExclusiveArch:  %{rust_arches}
 
 BuildRequires:  openssl-devel
@@ -47,7 +49,6 @@ BuildRequires:  python%{python3_pkgversion}-iso8601
 BuildRequires:  python%{python3_pkgversion}-pretend
 BuildRequires:  python%{python3_pkgversion}-pytest-benchmark
 BuildRequires:  python%{python3_pkgversion}-pytest-xdist
-BuildRequires:  python%{python3_pkgversion}-pytz
 %endif
 BuildRequires:  python%{python3_pkgversion}-pytest >= 6.2.0
 %endif
@@ -71,13 +72,13 @@ cryptography is a package designed to expose cryptographic primitives and
 recipes to Python developers.
 
 %prep
-%autosetup -p1 -n %{srcname}-%{version}
+%autosetup -p1 %{!?fedora:-a1} -n %{srcname}-%{version}
 %if 0%{?fedora}
 %cargo_prep
 sed -i 's/locked = true//g' pyproject.toml
 %else
 # RHEL: use vendored Rust crates
-%cargo_prep -V 1
+%cargo_prep -v vendor
 %endif
 
 %if ! 0%{?fedora}
@@ -89,9 +90,7 @@ sed -i 's,--benchmark-disable,,' pyproject.toml
 %pyproject_buildrequires
 %if 0%{?fedora}
 # Fedora: use RPMified crates
-cd src/rust
 %cargo_generate_buildrequires
-cd ../..
 %endif
 
 
@@ -101,6 +100,12 @@ export OPENSSL_NO_VENDOR=1
 export CFLAGS="${CFLAGS} -DOPENSSL_NO_ENGINE=1 "
 %pyproject_wheel
 
+%cargo_license_summary
+%{cargo_license} > LICENSE.dependencies
+%if ! 0%{?fedora}
+%cargo_vendor_manifest
+%endif
+
 
 %install
 # Actually other *.c and *.h are appropriate
@@ -114,8 +119,8 @@ find . -name Cargo.toml -print -delete
 %check
 %if %{with tests}
 %if 0%{?rhel}
-# skip benchmark, hypothesis, and pytz tests on RHEL
-rm -rf tests/bench tests/hypothesis tests/x509
+# skip benchmark and hypothesis tests on RHEL
+rm -rf tests/bench tests/hypothesis
 # append skipper to skip iso8601 and pretend tests
 cat < %{SOURCE2} >> tests/conftest.py
 %endif
@@ -139,6 +144,10 @@ PYTHONPATH=${PWD}/vectors:%{buildroot}%{python3_sitearch} \
 %files -n python%{python3_pkgversion}-%{srcname} -f %{pyproject_files}
 %doc README.rst docs
 %license LICENSE LICENSE.APACHE LICENSE.BSD
+%license LICENSE.dependencies
+%if ! 0%{?fedora}
+%license cargo-vendor.txt
+%endif
 
 
 %changelog
diff --git a/sources b/sources
index d10f2cb..e79ea50 100644
--- a/sources
+++ b/sources
@@ -1,2 +1,2 @@
-SHA512 (cryptography-44.0.0.tar.gz) = 6a0320ef3ece42e5b501d5381f719e01cb20b2971f0334a8a37f7b9a941482399901500f59817bffb1da579673e7785741a3016f51ac3bbf9bec55ff5df611ad
-SHA512 (cryptography-44.0.0-vendor.tar.bz2) = 53b52a5aac5de01ac878e5fb477e890b093e6886d8a0b210801402900000560d7a3b8a85414b81f0ff22aadf6f7bbd94ccace70666709197b97424207942af2b
+SHA512 (cryptography-45.0.4.tar.gz) = 08b35f414d81f83ee242f5d208f8aabc12dc53f1a0cbffc5be1ed7f9173e9c9863225a7eb5cff4e9f3dacf5e9fcb3e8701e33c441e1562ee13f9e3927fafb3df
+SHA512 (cryptography-45.0.4-vendor.tar.bz2) = 5ff616412e65bd342d2b98110d0b058aaa1719ddf0d1a1164b49451b8f5bc49def81cf4913b6b4c2917f28a33cef28a74ad4391b303c2e36752b81f491a4da06