diff --git a/imagecodecs_distributor_setup.py b/imagecodecs_distributor_setup.py
index c2ed243..b711920 100644
--- a/imagecodecs_distributor_setup.py
+++ b/imagecodecs_distributor_setup.py
@@ -1,3 +1,5 @@
+import platform
+
 def customize_build(EXTENSIONS, OPTIONS):
     """Customize build for Fedora"""
 
@@ -27,3 +29,6 @@ def customize_build(EXTENSIONS, OPTIONS):
     del EXTENSIONS['jpeg2k']  # Uses 3rdparty source to use private function - https://github.com/cgohlke/imagecodecs/issues/77
     EXTENSIONS['jpegxr']['include_dirs'].append('/usr/include/jxrlib')
     EXTENSIONS['zopfli']['include_dirs'].append('/usr/include/zopfli')
+
+    if platform.machine() == 's390x':
+        del EXTENSIONS['lzfse'] # Not supported on big-endian
diff --git a/python-imagecodecs.spec b/python-imagecodecs.spec
index 6a4bdc5..1a84145 100644
--- a/python-imagecodecs.spec
+++ b/python-imagecodecs.spec
@@ -12,6 +12,8 @@ Source:         %{pypi_source}
 Source1:        imagecodecs_distributor_setup.py
 Patch0:         python-imagecodecs-noexcept.patch
 
+ExcludeArch:    %{ix86}
+
 BuildRequires:  python3-devel
 BuildRequires:  python3-Cython
 BuildRequires:  gcc-c++
@@ -20,6 +22,7 @@ BuildRequires:  blosc2-devel
 BuildRequires:  bzip2-devel
 BuildRequires:  cfitsio-devel
 BuildRequires:  CharLS-devel
+BuildRequires:  brotli-devel
 BuildRequires:  giflib-devel
 BuildRequires:  jxrlib-devel
 BuildRequires:  lcms2-devel
@@ -33,7 +36,9 @@ BuildRequires:  libpng-devel
 BuildRequires:  libtiff-devel >= 4.5.0
 BuildRequires:  libzstd-devel
 BuildRequires:  lz4-devel
+%ifnarch s390x
 BuildRequires:  lzfse-devel
+%endif
 # Uses 3rdparty source to use private function - https://github.com/cgohlke/imagecodecs/issues/77
 #BuildRequires:  openjpeg2-devel
 BuildRequires:  snappy-devel
@@ -45,13 +50,16 @@ BuildRequires:  zopfli-devel
 BuildRequires:  %{py3_dist pytest}
 BuildRequires:  %{py3_dist blosc}
 BuildRequires:  %{py3_dist blosc2}
+BuildRequires:  %{py3_dist brotli}
 BuildRequires:  %{py3_dist lz4}
 BuildRequires:  %{py3_dist numcodecs}
-BuildRequires:  %{py3_dist pyliblzfse}
 BuildRequires:  %{py3_dist python-snappy}
 BuildRequires:  %{py3_dist tifffile}
 BuildRequires:  %{py3_dist zarr}
 BuildRequires:  %{py3_dist zstd}
+%ifnarch s390x
+BuildRequires:  %{py3_dist pyliblzfse}
+%endif
 
 %global _description %{expand:
 Imagecodecs is a Python library that provides block-oriented, in-memory