diff --git a/.gitignore b/.gitignore
index 7eb9f60..7a727fb 100644
--- a/.gitignore
+++ b/.gitignore
@@ -45,3 +45,4 @@
 /urllib3-2.1.0.tar.gz
 /urllib3-2.2.0.tar.gz
 /hypercorn-d1719f8c1570cbd8e6a3719ffdb14a4d72880abb.tar.gz
+/urllib3-2.2.1.tar.gz
diff --git a/python-urllib3.spec b/python-urllib3.spec
index 04c5259..d5d4c92 100644
--- a/python-urllib3.spec
+++ b/python-urllib3.spec
@@ -9,7 +9,7 @@
 %endif
 
 Name:           python-urllib3
-Version:        2.2.0
+Version:        2.2.1
 Release:        %autorelease
 Summary:        HTTP library with thread-safe connection pooling, file post, and more
 
@@ -47,23 +47,26 @@ BuildRequires:  %{py3_dist h2}
 # coverage==7.4.1: omitted linter/coverage tool
 # PySocks==1.7.1
 BuildRequires:  %{py3_dist PySocks}
-# pytest==7.4.2
+# pytest==7.4.4
 BuildRequires:  %{py3_dist pytest}
 # pytest-timeout==2.1.0
 BuildRequires:  %{py3_dist pytest-timeout}
-# pyOpenSSL==23.2.0
+# pyOpenSSL==24.0.0
 BuildRequires:  %{py3_dist pyOpenSSL}
 # idna==3.4
 BuildRequires:  %{py3_dist idna}
 # trustme==1.1.0
 BuildRequires:  %{py3_dist trustme}
-# cryptography==41.0.6
+# cryptography==42.0.2
 BuildRequires:  %{py3_dist cryptography}
 # backports.zoneinfo==0.2.1;python_version<"3.9"
 # towncrier==23.6.0: used for generating a changelog
-# pytest-memray==1.5.0;python_version>="3.8" and implementation_name=="cpython":
-#     not packaged, unwanted profiler
-# trio==0.23.1
+# pytest-memray==1.5.0;python_version<"3.13" and sys_platform!="win32" and
+#     implementation_name=="cpython": not packaged, unwanted profiler
+# trio==0.23.1;python_version<"3.13"
+# # We need a release of Trio newer than 0.24.0 to support CPython 3.13.
+# # https://github.com/python-trio/trio/issues/2903
+# trio @ git+https://github.com/python-trio/trio@e4c8eb2d7ef59eeea1441656e392fe1b0870a374; python_version == "3.13"
 BuildRequires:  %{py3_dist trio}
 # Quart==0.19.4
 BuildRequires:  %{py3_dist Quart}
@@ -76,6 +79,11 @@ BuildRequires:  %{py3_dist quart-trio}
 # hypercorn is packaged, but we need the forked/bundled version
 # httpx==0.25.2
 BuildRequires:  %{py3_dist httpx}
+# pytest-socket==0.7.0: not packaged, not strictly required
+# # CFFI is not going to support CPython 3.13 in an actual release until
+# # there is a release candidate for 3.13.
+# # https://github.com/python-cffi/cffi/issues/23#issuecomment-1845861410
+# cffi @ git+https://github.com/python-cffi/cffi@14723b0bbd127790c450945099db31018d80fa83; python_version == "3.13"
 %endif
 
 %global _description %{expand:
diff --git a/sources b/sources
index 06db068..0f1cec6 100644
--- a/sources
+++ b/sources
@@ -1,2 +1,2 @@
-SHA512 (urllib3-2.2.0.tar.gz) = 3914442c92980c9b803e7726228b147e326f71bf4ae7507b64474de6cb6df86e3e90026fd2f41e4f83e8bc6735b0f816cfc9945839a7cc5d0a86d31a5a8d6438
+SHA512 (urllib3-2.2.1.tar.gz) = 86713f54fe2a4c6c6ecfddfa939611526f81282162851d44e00d4b7ed21c3265b11a3ff506d685ddb88c0998f392809b7ffd08775608e309dd290fc30ab5d741
 SHA512 (hypercorn-d1719f8c1570cbd8e6a3719ffdb14a4d72880abb.tar.gz) = 62d6787d88a2e716f0ac04fc49f6cdc586e473a660ee754ff66961922ae78bcc75d1f78b091e78557dd60f006e8e480114738c7b4ff71beac804e4fc9603240b