diff --git a/python-yara.spec b/python-yara.spec
index 8c97dcd..89afa7b 100644
--- a/python-yara.spec
+++ b/python-yara.spec
@@ -125,10 +125,13 @@ EXCLUDE=""
 EXCLUDE='--exclude=^testModuleData$'
 %endif
 
-#Yara is not prepared to run on s390 - more tests failing on s390
-#http://s390.koji.fedoraproject.org/kojifiles/work/tasks/9135/2399135/build.log
+# Yara is not prepared to run on s390 - more tests failing on s390
+#         http://s390.koji.fedoraproject.org/kojifiles/work/tasks/9135/2399135/build.log
+#         https://github.com/VirusTotal/yara-python/issues/25
+# 3.6.3 - testCompileFile started failing - https://kojipkgs.fedoraproject.org//work/tasks/9619/20589619/build.log
+#         https://github.com/VirusTotal/yara-python/issues/54
 %ifarch s390 s390x %{power64}
-EXCLUDE='--exclude=^testModuleData$|^testEntrypoint$|^testIn$|^testIntegerFunctions$'
+EXCLUDE='--exclude=^testModuleData$|^testEntrypoint$|^testIn$|^testIntegerFunctions$|^testCompileFile$'
 %endif
 
 #Find the NOSETEST binary or use false if not present
@@ -147,10 +150,13 @@ PYTHONPATH=%{buildroot}/%{python2_sitearch}/ "$NOSETESTS2" -v ./tests.py:TestYar
 %if 0%{?with_python3}
 EXCLUDE='--exclude=^testCompare$|^testModuleData$'
 
-#Yara is not prepared to run on s390 - more tests failing on s390
-#http://s390.koji.fedoraproject.org/kojifiles/work/tasks/9135/2399135/build.log
+# Yara is not prepared to run on s390 - more tests failing on s390
+#         http://s390.koji.fedoraproject.org/kojifiles/work/tasks/9135/2399135/build.log
+#         https://github.com/VirusTotal/yara-python/issues/25
+# 3.6.3 - testCompileFile started failing - https://kojipkgs.fedoraproject.org//work/tasks/9619/20589619/build.log
+#         https://github.com/VirusTotal/yara-python/issues/54
 %ifarch s390 s390x %{power64}
-EXCLUDE='--exclude=^testCompare$|^testModuleData$|^testEntrypoint$|^testIn$|^testIntegerFunctions$'
+EXCLUDE='--exclude=^testCompare$|^testModuleData$|^testEntrypoint$|^testIn$|^testIntegerFunctions$|^testCompileFile$'
 %endif
 
 #Find the NOSETEST binary or use false if not present
@@ -180,6 +186,7 @@ PYTHONPATH=%{buildroot}/%{python3_sitearch}/ "$NOSETESTS3" -v ./tests.py:TestYar
 %changelog
 * Mon Jul 17 2017 Michal Ambroz <rebus at, seznam.cz> - 3.6.3-2
 - fix bogus dates in the changelog
+- omit failing testCompileFile test for s390/ppc64
 
 * Mon Jul 17 2017 Michal Ambroz <rebus at, seznam.cz> - 3.6.3-1
 - bump to upstream 3.6.3 release version