diff --git a/python3.10.spec b/python3.10.spec
index ed7b1b6..2c5aee0 100644
--- a/python3.10.spec
+++ b/python3.10.spec
@@ -246,6 +246,9 @@ BuildRequires: /usr/sbin/ifconfig
 %if %{with rpmwheels}
 BuildRequires: %{python_wheel_pkg_prefix}-setuptools-wheel
 BuildRequires: %{python_wheel_pkg_prefix}-pip-wheel
+%else
+# For %%python_wheel_inject_sbom
+BuildRequires: python-rpm-macros
 %endif
 
 %if %{without bootstrap}
@@ -1064,6 +1067,11 @@ for file in %{buildroot}%{pylibdir}/pydoc_data/topics.py $(grep --include='*.py'
     rm ${directory}/{__pycache__/${module}.cpython-%{pyshortver}.opt-?.pyc,${module}.py}
 done
 
+%if %{without rpmwheels}
+# Inject SBOM into the installed wheels (if the macro is available)
+%{?python_wheel_inject_sbom:%python_wheel_inject_sbom %{buildroot}%{pylibdir}/ensurepip/_bundled/*.whl}
+%endif
+
 # ======================================================
 # Checks for packaging issues
 # ======================================================