diff --git a/00457-ssl-raise-oserror-for-err_lib_sys.patch b/00457-ssl-raise-oserror-for-err_lib_sys.patch
new file mode 100644
index 0000000..0f8c5f4
--- /dev/null
+++ b/00457-ssl-raise-oserror-for-err_lib_sys.patch
@@ -0,0 +1,43 @@
+From 0000000000000000000000000000000000000000 Mon Sep 17 00:00:00 2001
+From: Victor Stinner <vstinner@python.org>
+Date: Thu, 3 Apr 2025 18:26:17 +0200
+Subject: [PATCH] 00457: ssl: Raise OSError for ERR_LIB_SYS
+
+The patch resolves the flakiness of test_ftplib
+
+Backported from upstream 3.10+:
+https://github.com/python/cpython/pull/127361
+
+Co-authored-by: Petr Viktorin <encukou@gmail.com>
+---
+ Modules/_ssl.c | 10 ++++++++++
+ 1 file changed, 10 insertions(+)
+
+diff --git a/Modules/_ssl.c b/Modules/_ssl.c
+index 3375b2bf3f..ab8a327d10 100644
+--- a/Modules/_ssl.c
++++ b/Modules/_ssl.c
+@@ -638,6 +638,11 @@ PySSL_SetError(PySSLSocket *obj, int ret, const char *filename, int lineno)
+                     errstr = "Some I/O error occurred";
+                 }
+             } else {
++                if (ERR_GET_LIB(e) == ERR_LIB_SYS) {
++                    // A system error is being reported; reason is set to errno
++                    errno = ERR_GET_REASON(e);
++                    return PyErr_SetFromErrno(PyExc_OSError);
++                }
+                 p = PY_SSL_ERROR_SYSCALL;
+             }
+             break;
+@@ -648,6 +653,11 @@ PySSL_SetError(PySSLSocket *obj, int ret, const char *filename, int lineno)
+             if (e == 0)
+                 /* possible? */
+                 errstr = "A failure in the SSL library occurred";
++            if (ERR_GET_LIB(e) == ERR_LIB_SYS) {
++                // A system error is being reported; reason is set to errno
++                errno = ERR_GET_REASON(e);
++                return PyErr_SetFromErrno(PyExc_OSError);
++            }
+             break;
+         }
+         default:
diff --git a/python3.6.spec b/python3.6.spec
index 79e9e61..35c5489 100644
--- a/python3.6.spec
+++ b/python3.6.spec
@@ -17,7 +17,7 @@ URL: https://www.python.org/
 #global prerel ...
 %global upstream_version %{general_version}%{?prerel}
 Version: %{general_version}%{?prerel:~%{prerel}}
-Release: 44%{?dist}
+Release: 45%{?dist}
 # Python is Python
 # pip MIT is and bundles:
 #   appdirs: MIT
@@ -816,6 +816,15 @@ Patch450: 00450-cve-2025-0938-disallow-square-brackets-and-in-domain-names-for-p
 # even when cross-compiling.
 Patch452: 00452-properly-apply-exported-cflags-for-dtrace-systemtap-builds.patch
 
+# 00457 # da99203f07d380d50ec780323bbebda00f227797
+# ssl: Raise OSError for ERR_LIB_SYS
+#
+# The patch resolves the flakiness of test_ftplib
+#
+# Backported from upstream 3.10+:
+# https://github.com/python/cpython/pull/127361
+Patch457: 00457-ssl-raise-oserror-for-err_lib_sys.patch
+
 # (New patches go here ^^^)
 #
 # When adding new patches to "python" and "python3" in Fedora, EL, etc.,
@@ -2085,6 +2094,9 @@ CheckPython optimized
 # ======================================================
 
 %changelog
+* Wed Apr 16 2025 Charalampos Stratakis <cstratak@redhat.com> - 3.6.15-45
+- Fix the flakiness of test_ftplib
+
 * Tue Apr 01 2025 Charalampos Stratakis <cstratak@redhat.com> - 3.6.15-44
 - Properly apply exported CFLAGS for dtrace/systemtap builds
 - Fixes: rhbz#2356306