diff --git a/vtk-ppc64-no-always-inline.patch b/vtk-ppc64-no-always-inline.patch
new file mode 100644
index 0000000..60d5bc5
--- /dev/null
+++ b/vtk-ppc64-no-always-inline.patch
@@ -0,0 +1,14 @@
+diff --git a/Common/Core/vtkDataArrayMeta.h b/Common/Core/vtkDataArrayMeta.h
+index 376244b..9b8f58e 100644
+--- a/Common/Core/vtkDataArrayMeta.h
++++ b/Common/Core/vtkDataArrayMeta.h
+@@ -43,7 +43,8 @@
+ #define VTK_ITER_ASSERT(x, msg)
+ #endif
+ 
+-#if defined(VTK_ALWAYS_OPTIMIZE_ARRAY_ITERATORS) && !defined(VTK_DEBUG_RANGE_ITERATORS)
++#if (defined(VTK_ALWAYS_OPTIMIZE_ARRAY_ITERATORS) || !defined(VTK_DEBUG_RANGE_ITERATORS)) &&       \
++  !defined(VTK_COMPILER_MSVC) && !defined(__PPC64__)
+ #define VTK_ITER_INLINE VTK_ALWAYS_INLINE
+ #define VTK_ITER_ASSUME VTK_ASSUME_NO_ASSERT
+ #define VTK_ITER_OPTIMIZE_START VTK_ALWAYS_OPTIMIZE_START
diff --git a/vtk.spec b/vtk.spec
index 3c2ae42..6933f09 100644
--- a/vtk.spec
+++ b/vtk.spec
@@ -60,6 +60,10 @@ Patch2: vtk-netcdf.patch
 Patch3: vtk-AllValues.patch
 # CVE-2021-42521 - vtkXMLTreeReader: possible nullptr dereference
 Patch4: https://gitlab.kitware.com/vtk/vtk/-/merge_requests/9621.patch
+# always_inline fails on ppc64le
+# https://gitlab.kitware.com/vtk/vtk/-/issues/19622
+# https://bugzilla.redhat.com/show_bug.cgi?id=2386242
+Patch5: vtk-ppc64-no-always-inline.patch
 
 URL: https://vtk.org/
 
@@ -848,6 +852,7 @@ cat xorg.log
 %changelog
 * Tue Nov 25 2025 Orion Poplawski <orion@nwra.com> - 9.1.0-20
 - Rebuild for gdal (rhbz#2416611)
+- Backport ppc64le inline patch
 
 * Tue Jun 24 2025 Orion Poplawski <orion@nwra.com> - 9.1.0-19
 - Rebuild for proj 9